Cluster Ions in Monocarboxylic Acid-Water Binary Systems Studied by Liquid Ionization Mass Spectrometry.

Cluster composition distributions of pure ethanol: influence of water and ion-molecule reactions revealed by liquid-ionization tandem mass spectrometry.

Studies of clusters in condensed phase at atmospheric pressure are very important for understanding the properties and structures of liquids. Liquid-ionization (LPI) mass spectrometry is useful to study hydrogen-bonded clusters at the liquid surface and in a gas phase. An improved ion source connected to a tandem mass spectrometer provides detailed information about clusters. Mass spectra of pu...

pharmacokinetics and bioequivalence of methotrexate in human plasma studied by liquid chromatography-mass spectrometry (lc-ms)

background methotrexate is a folic acid antagonist that has been in clinical use for five decades. its use in patients with brain tumors is primarily confined to primary central nervous system lymphoma (pcnsl), in which it is the cornerstone of chemotherapy. objectives a selective and sensitive high-performance liquid chromatography-electrospray ionization-mass spectrometry method was developed...

Comprehensive Biothreat Cluster Identification by PCR/Electrospray-Ionization Mass Spectrometry

Technology for comprehensive identification of biothreats in environmental and clinical specimens is needed to protect citizens in the case of a biological attack. This is a challenge because there are dozens of bacterial and viral species that might be used in a biological attack and many have closely related near-neighbor organisms that are harmless. The biothreat agent, along with its near n...

Forensic DNA fingerprinting by liquid chromatography-electrospray ionization mass spectrometry.

The determination of the molecular mass of a DNA sequence has several benefits over conventional fragment-length analysis that are advantageous to the forensic field: (i) sequence variation is captured that increases the power of discrimination compared with that obtained by conventional fragment-length analysis. First experiments showed that this increase makes up to 20%-30% for STR analysis. ...

Determination of valproic acid in serum by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.